2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → HCID 54081787, compound

HRID 903172Notes

Reaction equation

HRID 903172 reaction equation
[C:1]([CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[N:6]=1)[OH:4])#[N:2].[C:20]([CH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[N:25]=1)[OH:23])#[N:21].[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51](O)=[O:52]>>[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51]([O:4][CH:3]([C:1]#[N:2])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[N:6]=1)=[O:52].[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51]([O:23][CH:22]([C:20]#[N:21])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[N:25]=1)=[O:52]

Participants

5

Reactant 3

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 21163943Cyano[6-(2-fluorophenoxy)-2-pyridyl]methanolHCID 23337847HCID 23337847, compound

Product 2

HCID 54081787HCID 54081787, compoundHCID 54290686HCID 54290686, compound

Procedure

The alcohol, cyano[6-(3,4-dimethylphenoxy)-2-pyridyl]methanol and cyano[6-(2-fluorophenoxy)-2-pyridyl]methanol, is reacted with the acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid to yield cyano[6-(3,4-dimethylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate and cyano[6-(2-fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate.

Sources & evidence

ORD record
ord-da27be299ccc49f090178a84266d71be
Source dataset
uspto-grants-1980_10
Patent number
US04226872

Reaction notes

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