HRID903172

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3947643

2‐{[2‐Chloro‐4‐(trifluoromethyl)phenyl]amino}‐3‐ methylbutanoic acid

C12H13ClF3NO2

HCID21163943

未命名化合物

HCID23337847

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(Nc1ccc(C(F)(F)F)cc1Cl)C(=O)OC(C#N)c1cccc(Oc2ccccc2F)n1

HCID54081787

未命名化合物

结构：Cc1ccc(Oc2cccc(C(C#N)OC(=O)C(Nc3ccc(C(F)(F)F)cc3Cl)C(C)C)n2)cc1C

HCID54290686

未命名化合物

PROCEDURE

实验过程

The alcohol, cyano[6-(3,4-dimethylphenoxy)-2-pyridyl]methanol and cyano[6-(2-fluorophenoxy)-2-pyridyl]methanol, is reacted with the acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid to yield cyano[6-(3,4-dimethylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate and cyano[6-(2-fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da27be299ccc49f090178a84266d71be
来源数据集: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04226872
来源说明: uspto-grants-1980_10

反应 SMILES

[C:1]([CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[N:6]=1)[OH:4])#[N:2].[C:20]([CH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[N:25]=1)[OH:23])#[N:21].[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51](O)=[O:52]>>[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51]([O:4][CH:3]([C:1]#[N:2])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[N:6]=1)=[O:52].[Cl:38][C:39]1[CH:44]=[C:43]([C:45]([F:48])([F:47])[F:46])[CH:42]=[CH:41][C:40]=1[NH:49][CH:50]([CH:54]([CH3:56])[CH3:55])[C:51]([O:23][CH:22]([C:20]#[N:21])[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[N:25]=1)=[O:52]