2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → HCID 54179426, compound

HRID 903174Notes

Reaction equation

HRID 903174 reaction equation
[CH2:1]([CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:6]=1)[OH:4])[CH3:2].[Cl:18][C:19]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:20]=1[NH:29][CH:30]([CH:34]([CH3:36])[CH3:35])[C:31](O)=[O:32]>>[Cl:18][C:19]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:20]=1[NH:29][CH:30]([CH:34]([CH3:36])[CH3:35])[C:31]([O:4][CH:3]([CH2:1][CH3:2])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:6]=1)=[O:32]

Participants

3

Reactant 2

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 23337858HCID 23337858, compound

Product 1

HCID 54179426HCID 54179426, compound

Procedure

Using the procedure of Example 11, α-ethyl(6-phenoxy-2-pyridyl)methanol is reacted with 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid to yield α-ethyl(6-phenoxy-2-pyridyl)methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, MS m/e 506 (M+).

Sources & evidence

ORD record
ord-4f403000f0044f9db8de92853cf5ff8b
Source dataset
uspto-grants-1980_10
Patent number
US04226872

Reaction notes

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