4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane → 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

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Reaction Steps

15.05 g. of 2,2-dimethyl-4-chloromethyl-1,3-dioxolane is dissolved in 100 ml. DMF and 6.5 g. of NaN3 are added. The mixture is stirred at 50° overnight, cooled to room temperature, diluted with 300 ml. C6H6 and washed 5 times with water. The organic phase is dried and evaporated under reduced pressure to give 2,2-dimethyl-4-azidomethyl-1,3-dioxolane.

Provenance & Evidence