Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrimidylmethylthio)ethyl]urea

HRID 903224Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:11]=[CH:10][CH:9]=[CH:8][N:7]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][CH:9]=[CH:10][N:11]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 202424852-[(2-Aminoethyl)thiomethyl]pyrimidine

Product 1

HCID 20557598N-Methyl-N'-[2-(2-pyrimidylmethylthio)ethyl]urea

Procedure

By the procedure of Example 24, 2-[(2-aminoethyl)thiomethyl]pyrimidine is reacted with methyl isocyanate to give the title compound.

Sources & evidence

ORD record: ord-0e18350718154c61adcb4875c5c3111a
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04226874

Reaction notes

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