Methyl Isocyanate → N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

HRID 903245Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[N:2]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:3]1[N:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 21698444N-(3-pyridazinylmethyl)ethylenediamine

Product 1

HCID 20557601N-Methyl-N'-[2-(3-pyridazinylmethylamino)ethyl]urea

Procedure

Reacting N-(3-pyridazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-ed8a784dfc91406da7d64cf42caed07e
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04226874

Reaction notes

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