Methyl 5-bromovalerate → 5,5-Diphenylhydantoin

HRID 903318Notes

Reaction equation

HRID 903318 reaction equation
[C:1]1([C:7]2([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:11][C:10](=[O:12])[NH:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na].BrCCCCC(OC)=O>>[CH:17]1[CH:18]=[CH:19][C:14]([C:7]2([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:11][C:10]([OH:12])=[N:9][C:8]2=[O:13])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 79557Methyl 5-bromovalerateHCID 97955475,5-Diphenylhydantoin sodium

Product 1

HCID 17755,5-Diphenylhydantoin

Procedure

Following the method of cook et al, Res. Comm. Chem. Path. Pharm. 5:767(1973), sodium diphenylhydantoin is reacted with methyl 5-bromovalerate followed by acid hydrolysis to yield the following: ##STR14##

Workup

  1. customfollowed by acid hydrolysis
  2. customto yield the following: ##STR14##

Sources & evidence

ORD record
ord-3b0fcddb0d1240c0a3844f444e89707c
Source dataset
uspto-grants-1980_10
Patent number
US04226992

Reaction notes

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