反应详情

A stirred mixture of 3-(6-methyl-3-pyridyl)acrylic acid (50.70 g), dry ethanol (350 ml) and concentrated sulphuric acid (25 ml) was heated under reflux for 18 hours and ethanol (~250 ml) was removed by evaporation. The residue was poured into ice-aqueous ammonia and the mixture was extracted with ether. The ether extracts were washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methyl-3-pyridyl)acrylate, m.p. 36°-37°.

1. temperaturewas heated
2. temperatureunder reflux for 18 hours
3. customethanol (~250 ml) was removed by evaporation
4. additionThe residue was poured into ice-aqueous ammonia
5. extractionthe mixture was extracted with ether
6. washThe ether extracts were washed with water
7. customevaporated to an oil which
8. customcrystallised