2-Chloro-4-cyanopyridine → 2-Methoxyisonicotinonitrile

Participants

Reaction Steps

2-Chloro-4-cyanopyridine (115.5 g) in methanoldioxan (1:1, 850 ml) was added to a solution of sodium methoxide (prepared from 20.8 g sodium) in methanol (285 ml) and the mixture was heated under reflux for 2.5 hours and then allowed to cool. The mixture was filtered and the volume of the filtrate was reduced by evaporation to 200 ml and water (400 ml) was added. The solid which precipitated was filtered off to give 2-methoxy-4-cyanopyridine (57.2 g, 51%), m.p. 93°-95.5°.

Provenance & Evidence