Ethanol → 2-Methoxypyridine-4-carbaldehyde

A mixture of 2-methoxy-4-cyanopyridine (57.2 g), semicarbazide hydrochloride (71.24 g), sodium acetate (69.86 g), ethanol (1200 ml) and water (370 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g). The mixture was evaporated to a volume of 450 ml, water (900 ml) was added and the mixture was allowed to stand at 0° overnight. The mixture was filtered and the solid residue was washed with water and then dissolved in 10% hydrochloric acid (950 ml). Formaldehyde solution (36% w/v, 420 ml) was added and the mixture was warmed for 30 minutes, allowed to cool and added to a solution of sodium acetate (290 g) in water (840 ml). The mixture was extracted with ether and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 2-methoxypyridine-4-carboxaldehyde (20.53 g, 35%), m.p. 33°-35°. A sample recrystallised from light petroleum had m.p. 33°-36°.

1. customThe mixture was evaporated to a volume of 450 ml, water (900 ml)
2. additionwas added
3. filtrationThe mixture was filtered
4. washthe solid residue was washed with water
5. dissolutiondissolved in 10% hydrochloric acid (950 ml)
6. additionFormaldehyde solution (36% w/v, 420 ml) was added
7. temperaturethe mixture was warmed for 30 minutes
8. temperatureto cool
9. additionadded to a solution of sodium acetate (290 g) in water (840 ml)
10. extractionThe mixture was extracted with ether
11. washthe combined extracts were successively washed with aqueous potassium carbonate and water
12. customwere dried
13. customevaporated

ORD record

ord-0314ea07c694497a87f0fdaf935aa80c

Source dataset

uspto-grants-1980_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04227000