HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → Ethyl 2-formyl-3-(2-methoxy-4-pyridyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Methoxypyridine-4-carbaldehyde | HCID 2762996 | — |
| Product | Ethyl 2-formyl-3-(2-methoxy-4-pyridyl)propionate | HCID 21273312 | — |
Reaction Steps
Condensation of 2-methoxypyridine-4-carboxaldehyde with malonic acid with subsequent esterification and hydrogenation at 344 kPa and formylation of the product with ethyl formate and sodium hydride gave ethyl 2-formyl-3-(2-methoxy-4-pyridyl)propionate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04227000 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-5be667ac1cc74ae7bac0a72b4f155307 |
| Source note | uspto-grants-1980_10 |