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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 903357Generated: October 30, 2026

Ethyl formate → Ethyl 2-formyl-3-(3,4,5-trimethoxyphenyl)propanoate

https://huagongshe.com/reaction/903357

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl formateHCID 8025—
ReactantSodium hydrideHCID 24758—
ReactantEthyl 3-(3,4,5-trimethoxyphenyl)propionateHCID 622665—
Solvent1,2-DimethoxyethaneHCID 8071—
ProductEthyl 2-formyl-3-(3,4,5-trimethoxyphenyl)propanoateHCID 301837644%

Reaction Steps

Ethyl 3-(3,4,5-trimethoxyphenyl)propionate was reacted with ethyl formate and sodium hydride in 1,2-dimethoxyethane to give crude ethyl 2-formyl-3-(3,4,5-trimethoxyphenyl)-propionate in 44% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04227000
Source datasetuspto-grants-1980_10
ORD IDord-69851cc020684ecd93381f934307b031
Source noteuspto-grants-1980_10