HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloromethyl-3,4-dimethoxypyridinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,4-Dimethoxy-2-pyridinemethanol | HCID 10725809 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Chloromethyl-3,4-dimethoxypyridinium chloride | HCID 16216928 | — |
Reaction Steps
2-Hydroxymethyl-3,4-dimethoxypyridine was reacted with thionyl chloride in chloroform to give 2-chloromethyl-3,4-dimethoxypyridine hydrochloride, m.p. 158°-9° (decomp), which was reacted with cysteamine hydrochloride and sodium ethoxide in ethanol to give 2-(3,4-dimethoxy-2-pyridylmethylthio)-ethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04227000 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-6098d5e0de424a8cba261b14515832c1 |
| Source note | uspto-grants-1980_10 |