反应详情

Ethyl 2-formyl-3-(2-furyl)propionate (24.0 g, 0.122 mol) was added to a mixture of nitroguanidine (12.69 g, 0.122 mol) and sodium methoxide (from 3.09 g, 0.134 mol, sodium) in methanol and the mixture was stirred and heated under reflux for 18 hours and evaporated to dryness. The residue was dissolved in water and the solution was adjusted to pH 4 with acetic acid. The solid which separated was filtered off to give 2-nitroamino-5-(2-furylmethyl)-4-pyrimidone (17.1 g, 59%). A sample recrystallised from methanol-acetic acid and from acetic acid had m.p. 183°-184°.

1. temperatureheated
2. temperatureunder reflux for 18 hours
3. customevaporated to dryness
4. dissolutionThe residue was dissolved in water
5. customThe solid which separated
6. filtrationwas filtered off