反应详情

Ethyl 2-formyl-3-(3-methoxyphenyl)propionate (10 g) was added dropwise to a stirred and boiling mixture of sodium methoxide (from 1.15 g sodium) and nitroguanidine (25% wet, 5.5 g) in methanol (250 ml) and the mixture was heated under reflux for 20 hours and evaporated to dryness. The residue was dissolved in water (100 ml), the solution was extracted with ether and the aqueous phase was adjusted to pH 4: the solid which separated was recrystallised from ethanol to give 2-nitroamino-5-(3-methoxybenzyl)-4-pyrimidone (3.41 g, 29%), m.p. 178°-9°.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 20 hours
3. customevaporated to dryness
4. dissolutionThe residue was dissolved in water (100 ml)
5. extractionthe solution was extracted with ether
6. customthe solid which separated
7. customwas recrystallised from ethanol