HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramide → 2-[4-(3-Amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{6-Oxo-5-[(pyridin-3-yl)methyl]-1,6-dihydropyrimidin-2-yl}nitramide | HCID 12788688 | — |
| Reactant | 2-(4-Aminobutyl)pyridin-3-amine | HCID 13350838 | — |
| Product | 2-[4-(3-Amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone | HCID 20279284 | — |
Reaction Steps
Using a procedure similar to that of Example 16, 2-nitroamino-5-(3-pyridylmethyl)-4-pyrimidone was reacted with 1.1 molar equivalents of 4-(3-amino-2-pyridyl)butylamine, to give 2-[4-(3-amino-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone, m.p. 130°-1.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04227000 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-fea8c6f473634658b39d4bb1000c308e |
| Source note | uspto-grants-1980_10 |