反应详情

温度

60 °C

0.06 mol=20.73 g of 2-[4'-(2",4"-dichlorophenoxy)phenoxy]-propionic acid chloride dissolved in 30 ml absolute toluene were added dropwise at room temperature to a solution of 0.06 mol=6.9 g of 2-pyrrolidino-ethanol in 50 ml absolute toluene and the mixture was stirred for a further hour at 60° C. After cooling to 0° C., the formed precipitate was filtered off and recrystallized from acetone. 21.0 g=76% of the theory of 2-[4'-(2",4"-dichloro-phenoxy)phenoxy]-propionic acid 2-pyrrolidino-eth-1-yl ester hydrochloride were obtained melting at 160°-162° C. ##STR17##

1. temperatureAfter cooling to 0° C.
2. filtrationthe formed precipitate was filtered off
3. customrecrystallized from acetone