4-(8-Cyclohexyloctylamino)benzoic acid → p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride

HRID 903408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903408
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(COC)OC.C(Cl)[Cl:32]>>[ClH:32].[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([Cl:32])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 204757724-(8-Cyclohexyloctylamino)benzoic acidHCID 86634710Dimethoxyethane methylene chloride

Produkt 1

HCID 20475769p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride

Versuchsvorschrift

A cold solution of 25 g. 4-(8-cyclohexyloctylamino)benzoic acid in 500 ml. dimethoxyethane-methylene chloride (4:1) is prepared and dry hydrochloric acid is bubbled through the solution until no more precipitate forms. The solution is treated with 25 ml. thionyl chloride and refluxed until all of the precipitate has dissolved. The solvents are evaporated to yield an orange, semi-crystalline mass.

Aufarbeitung

  1. customdry hydrochloric acid is bubbled through the solution until no more precipitate forms
  2. additionThe solution is treated with 25 ml
  3. temperaturethionyl chloride and refluxed until all of the precipitate
  4. dissolutionhas dissolved
  5. customThe solvents are evaporated
  6. customto yield an orange, semi-crystalline mass

Quellen und Nachweise

ORD-Eintrag
ord-04f29152b0df4c718368984afc708c8e
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04227014

Notizen zur Reaktion

Wird geladen…