HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypyridine → 3-Pyridyl 4-(8-cyclohexyloctylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-(8-Cyclohexyloctylamino)benzoic acid | HCID 20475772 | — |
| Catalyst | Sodium hydride | HCID 24758 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Pyridyl 4-(8-cyclohexyloctylamino)benzoate | HCID 20475783 | — |
Reaction Steps
A 6 g. sample of 4-(8-cyclohexyloctylamino)benzoic acid and 2.7 g. 1,1'-carbonyldiimidazole in 50 ml. dry tetrahydrofuran is stirred for 2 hours. Then, 1.58 g. 3-hydroxypyridine and a trace of sodium hydride catalyst is added and the reaction is refluxed for 3 hours. The solution is cooled, filtered, and evaporated. The product is crystallized from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04227014 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-5797aaaee66140739934c475e351bc0b |
| Source note | uspto-grants-1980_10 |