HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[3-(4-Bromobenzoyl)propionyl]-L-proline methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(4-Bromobenzoyl)propionic acid | HCID 80646 | — |
| Reactant | 1-Methyl-L-proline hydrochloride | HCID 66599912 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[3-(4-Bromobenzoyl)propionyl]-L-proline methyl ester | HCID 22812447 | — |
Reaction Steps
The procedure of Example 28 is repeated, using 21.8 ml. of triethylamine in place of the diisopropylethylamine and using 27.3 g. of 3-(4bromobenzoyl)propionic acid, hydroxysuccinimide ester 13.0 g. of methylproline hydrochloride and 150 ml. of acetonitrile. The desired product is recovered as 16.6 g. of white crystals, m.p. 83°-85° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226775 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-d0482ff930ee4bfa9344035fd595597e |
| Source note | uspto-grants-1980_10 |