Sodium Hydroxide → 1-[3-(4-Bromobenzoyl)propionyl]-L-proline

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Reaction Steps

A mixture of 2.64 g. of 1-[3-(4-bromobenzoyl)propionyl]-L-proline methyl ester (Example 26) and 26 ml. of 1 N sodium hydroxide is stirred at room temperature. The solids are collected by decantation, dissolved in tetrahydrofuran and returned to the alkaline solution which is stirred further at room temperature. This alkaline solution is washed with ethyl acetate and poured into iced hydrochloric acid. This mixture is extracted with dichloromethane. The organic extract is dried over magnesium sulfate and evacuated to dryness in vacuo leaving a gum. This gum is triturated with ether giving white crystals which are recrystallized from acetone-hexane giving the desired product as 1.35 g. of white crystals, mp. 138°-139° C.

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