反应详情

To a stirred suspension of 469 mg. of potassium thioacetate in 10 ml. of ethanol is added 1.76 g. of 1-[3-(4-bromobenzoyl)-3-bromopropionyl]-L-proline (Example 37). The mixture is stirred at room temperature for 18 hours, filtered and the filtrate evaporated to dryness. The residue is dissolved in dichloromethane, washed with water and saturated sodium chloride solution, dried over magnesium sulfate and evaporated to dryness in vacuo giving the desired product as 1.68 g. of a white glass.

1. additionTo a stirred suspension of 469 mg
2. filtrationfiltered
3. customthe filtrate evaporated to dryness
4. dissolutionThe residue is dissolved in dichloromethane
5. washwashed with water and saturated sodium chloride solution
6. dry with materialdried over magnesium sulfate
7. customevaporated to dryness in vacuo