Hydrochloric Acid → HCID 54175967, compound

Participants

Reaction Steps

A 1.98 g. portion of 1-[3-(3-fluorobenzoyl)-2-methylpropionyl]-L-proline methyl ester (Example 44) is dissolved in 2 ml. of tetrahydrofuran and 20 ml. of 1 N sodium hydroxide is added. The mixture is stirred at room temperature for 4 hours, cooled in an ice bath, acidified with concentrated hydrochloric acid and extracted with dichloromethane. The organic extract is washed with sodium chloride solution, dried over magnesium sulfate and evaporated in vacuo to a gum. This gum is triturated with ether giving the desired product as 500 mg. of a white solid.

Provenance & Evidence