HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-[3-bromo-3-(3-trifluoromethylbenzoyl)propionyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 4-Oxo-4-(3-trifluoromethylphenyl)butyric acid | HCID 13408836 | — |
| Reactant | 1-[3-(3-trifluoromethylbenzoyl)propionyl]-L-proline | HCID 53668363 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-[3-bromo-3-(3-trifluoromethylbenzoyl)propionyl]-L-proline | HCID 54098687 | — |
Reaction Steps
As described in Example 15, 3-(3-trifluoromethylbenzoyl)propionic acid, hydroxysuccinimide ester is prepared and coupled to L-proline as in Example 16. The 1-[3-(3-trifluoromethylbenzoyl)propionyl]-L-proline in acetic acid is reacted with bromine as in Example 20 to give 1-[3-bromo-3-(3-trifluoromethylbenzoyl)propionyl]-L-proline. The preceding compound is reacted with potassium thioacetate in ethanol-water (1:1) as in Example 21 to give the product of the Example as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226775 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-56d6cc1ee1f34d31aa644ee31479ded1 |
| Source note | uspto-grants-1980_10 |