HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4,5-Trimethoxybenzaldehyde → HCID 54001398, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4,5-Trimethoxybenzaldehyde | HCID 6858 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 4-oxo-4-(3,4,5-trimethoxyphenyl)butanoic acid | HCID 290094 | — |
| Reactant | HCID 54468486 | HCID 54468486 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 54001398 | HCID 54001398 | — |
Reaction Steps
As described in Example 52, 3,4,5-trimethoxybenzaldehyde is converted to 3-(3,4,5-trimethoxybenzoyl)propionic acid. The preceding compound is converted to the hydroxysuccinimide ester as described in Example 15 and coupled to L-proline as described in Example 16. The 1-[3-(3,4,5-trimethoxybenzoyl)propionyl]-L-proline is reacted with bromine in acetic acid as in Example 20 to give 1-[3-bromo-3-(3,4,5-trimethoxybenzoyl)propionyl]-L-proline. The preciding compound is reacted with potassium thioacetate in ethanol-water as in Example 21 to give the product of the Example as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226775 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-ad7c7ef94e024921a903ffe6faf92334 |
| Source note | uspto-grants-1980_10 |