HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-{2-[(Acetylsulfanyl)methyl]-6-methyl-5-oxoheptanoyl}-L-proline | HCID 54274546 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline | HCID 54328960 | — |
Reaction Steps
1-[2-(acetylthiomethyl)-5-oxo-6-methylheptanoyl]-L-proline (1.5 g.) is dissolved in cold methanol (10 ml.) and sodium borohydride (0.12 g.) is added. After two hours the reaction mixture is diluted with water (100 ml.) acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness in vacuo to give 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04228077 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-2d49105f750e40de967cfc493c898855 |
| Source note | uspto-grants-1980_10 |