1-[3-acetylthio-2-(methylthiomethyl)propanoyl]-L-proline → 1-[2-mercaptomethyl-5-hydroxy-6-methylheptanoyl]-L-proline

HRID 903508Notes

Reaction equation

HRID 903508 reaction equation
C([S:4][CH2:5][CH:6]([CH2:17][CH2:18][CH:19]([OH:23])[CH:20]([CH3:22])[CH3:21])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.C(SCC(CSC)C(N1CCC[C@H]1C(O)=O)=O)(=O)C>>[SH:4][CH2:5][CH:6]([CH2:17][CH2:18][CH:19]([OH:23])[CH:20]([CH3:21])[CH3:22])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 539119981-[3-acetylthio-2-(methylthiomethyl)propanoyl]-L-prolineHCID 543289601-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline

Product 1

HCID 537047441-[2-mercaptomethyl-5-hydroxy-6-methylheptanoyl]-L-proline

Procedure

By substituting 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline for the 1-[3-acetylthio-2-(methylthiomethyl)propanoyl]-L-proline in the procedure of Example 17, 1-[2-mercaptomethyl-5-hydroxy-6-methylheptanoyl]-L-proline is obtained.

Sources & evidence

ORD record
ord-d82c888f838043a992521d01590ff584
Source dataset
uspto-grants-1980_10
Patent number
US04228077

Reaction notes

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