Dimethylthiocarbamoyl chloride → HCID 20551392, compound

Participants

Reaction Steps

Alternatively, N-acetyl-8-chloro-7-mercapto-1,2,3,4-tetrahydroisoquinoline can be prepared by reacting 8-chloro-7-hydroxyisoquinoline with dimethylthiocarbamyl chloride and rearranging the resulting compound to 8-chloro-7-dimethylcarbamoylthioisoquinoline. This compound is hydrolyzed to give 8-chloro-7-mercaptoisoquinoline which is then reduced and acylated.

Provenance & Evidence