Dimethylformamide → HCID 23336597, compound

Participants

Reaction Steps

To (122 g., 0.68 m.) 8-chloro-7-hydroxyisoquinoline in 180 ml. of dimethylformamide was added (450 g., 4.5 m.) triethylamine followed by (140 g., 0.87 m) dimethylthiocarbamoyl chloride. The mixture was stirred for four hours at room temperature and then poured into 5400 ml. of water. The resulting solid was collected by filtration, dried, dissolved in chloroform, dried with sodium sulfate and evaporated to yield 8-chloro-7-dimethylthiocarbamoylisoquinoline.

Provenance & Evidence