Sodium Hydroxide → HCID 20551392, compound

Participants

Reaction Steps

To a stirred solution (213 g., 0.08 m.) of 8-chloro-7-dimethylcarbamoylthioisoquinoline in 750 ml of methanol was slowly added 77 ml. of 10% aqueous sodium hydroxide under a nitrogen atmosphere. The resulting solution is refluxed 1.5 hours, cooled, concentrated at reduced pressure, diluted with 90 ml. of water and adjusted to pH 6-7 with glacial acetic acid. The resulting precipitate was collected by filtration, washed with cold water and dried to yield 8-chloro-7-mercaptoisoquinoline, m.p. 118°-122° C.

Provenance & Evidence