Methyl 4-chloroformylbutyrate → HCID 23336466, compound

HRID 903588Notes

Reaction equation

HRID 903588 reaction equation
[CH2:1]([NH:6][CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH3:18][O:19][C:20]([CH2:22][CH2:23][CH2:24][C:25](Cl)=[O:26])=[O:21]>>[CH2:1]([N:6]([C:25](=[O:26])[CH2:24][CH2:23][CH2:22][C:20]([O:19][CH3:18])=[O:21])[CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 73916Methyl 4-chloroformylbutyrateHCID 23336456HCID 23336456, compound

Product 1

HCID 23336466HCID 23336466, compoundYield 71.9%

Procedure

13.4 g of N-pentyl-tryptamine and 10.5 g of 4-methoxycarbonylbutyryl chloride were treated in the same manner as described in Example 1. 14.9 g of N-pentyl-N-(4-methoxycarbonylbutyryl)-tryptamine (i.e., 3-[2-(N-pentyl-4-methoxycarbonylbutanamido)ethyl]-indole) were thereby obtained. Yield: 71.9%

Sources & evidence

ORD record
ord-deee79b8427a4b6aaedc577941d0fedf
Source dataset
uspto-grants-1980_10
Patent number
US04228168

Reaction notes

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