HCID 41419, compound → HCID 23336487, compound

HRID 903589Notes

Reaction equation

HRID 903589 reaction equation
[CH:1]1([CH2:4][NH:5][CH2:6][CH2:7][C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:3][CH2:2]1.[CH3:17][O:18][C:19]([CH2:21][CH2:22][CH2:23][C:24](Cl)=[O:25])=[O:20]>>[CH:1]1([CH2:4][N:5]([C:24](=[O:25])[CH2:23][CH2:22][CH2:21][C:19]([O:18][CH3:17])=[O:20])[CH2:6][CH2:7][C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 41419HCID 41419, compoundHCID 73916Methyl 4-chloroformylbutyrate

Product 1

HCID 23336487HCID 23336487, compoundYield 60.3%

Procedure

10.5 g of N-cyclopropylmethyl-tryptamine (i.e., 3-(2-cyclopropylmethylaminoethyl)-indole) and 9.7 g of 4-methoxycarbonylbutyryl chloride were treated in the same manner as described in Example 1. 10.1 g of N-cyclopropylmethyl-N-(4-methoxycarbonylbutyryl)-tryptamine (i.e., 3-[2-(N-cyclopropylmethyl-4-methoxycarbonylbutanamido)ethyl]-indole) were thereby obtained. Yield: 60.3%

Sources & evidence

ORD record
ord-a3dfd37ba6764ed0b6b56437ad121705
Source dataset
uspto-grants-1980_10
Patent number
US04228168

Reaction notes

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