Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 903591Generated: October 26, 2026

Methyl 4-chloroformylbutyrate → N-cyclohexylmethyl-N-(4-methoxycarbonylbutyryl)-tryptamine

https://huagongshe.com/reaction/903591

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-chloroformylbutyrateHCID 73916—
ReactantN-(cyclohexylmethyl)-2-(1H-indol-3-yl)ethanamineHCID 17158300—
ProductN-cyclohexylmethyl-N-(4-methoxycarbonylbutyryl)-tryptamineHCID 2333645484.9%

Reaction Steps

12.0 g of N-cyclohexylmethyl-tryptamine and 8.47 g of 4-methoxycarbonylbutyryl chloride were treated in the same manner as described in Example 1. 15.2 g of N-cyclohexylmethyl-N-(4-methoxycarbonylbutyryl)-tryptamine (i.e., 3-[2-(N-cyclohexylmethyl-4-methoxycarbonylbutanamido)-ethyl]-indole) were thereby obtained. Yield: 84.9%

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04228168
Source datasetuspto-grants-1980_10
ORD IDord-531fa71487414d9b928547863cf1875d
Source noteuspto-grants-1980_10