Hydrochloric Acid → HCID 23336482, compound

Participants

Reaction Conditions

Reaction Steps

1.5 ml of an aqueous 10% sodium hydroxide solution and 10 ml of a mixture of methanol and water (1:1) were added to 0.63 g of N-isobutyl-N-(4-methoxycarbonylbutyryl)-tryptamine (i.e., 3-[2-(N-isobutyl-4-methoxycarbonylbutanamido)ethyl]-indole). The mixture was stirred at 60° C. for 30 minutes. After the reaction was completed, the mixture was evaporated to remove solvent. The residue thus obtained was adjusted to a pH of 2.0 with 10% hydrochloric acid, and then extracted with chloroform. The extract was washed with water and concentrated. 0.6 g of N-isobutyl-N-(4-carboxybutyryl)-tryptamine (i.e., 3-[2-(N-isobutyl-4-carboxybutanamido)ethyl]-indole) were thereby obtained. Yield: 99.3%

Provenance & Evidence