p-Toluenesulfonic acid → HCID 23336922, compound

Participants

Reaction Steps

5.18 g of 2-acetylamino-4-methanesulfonyloxy-5-methylphenol and 0.8 g of p-toluenesulfonic acid were added to 100 ml of toluene and heated at reflux for 12 hours. After cooling and washing with water, concentration under a reduced pressure yielded crude crystals of 5-methanesulfonyloxy-2,6-dimethylbenzoxazole. Immediately the product was dissolved in 50 ml of methanol, to which 5 ml of water containing 2 g of sodium hydroxide was added. A crystalline product was obtained after 1 hour of reflux followed by neutralization with hydrochloric acid after cooling.

Provenance & Evidence