L-Alanine → HCID 178454579, compound

HRID 903680Notes

Reaction equation

HRID 903680 reaction equation
C([O:8][C:9](=[O:22])[C@H](CCCNC(=N)N)N[N+]([O-])=O)C1C=CC=CC=1.N[C@H](C(O)=O)C.C([O:36][C:37](=[O:59])[C@H:38]([CH2:52][CH2:53][CH2:54][NH:55][C:56](=[NH:58])[NH2:57])[N:39]([N+]([O-])=O)[C:40](=[O:48])[CH:41]([CH3:47])[CH2:42]C(OC)=O)C1C=CC=CC=1.COC(CC(C)C(N[C@H](C(O)=O)CCCNC(=N)N)=O)=O>>[C:9]([CH:52]([CH2:53][CH2:54][NH:55][C:56](=[NH:58])[NH2:57])[C@@H:38]([C:37]([OH:36])=[O:59])[NH:39][C:40](=[O:48])[CH:41]([CH3:42])[CH3:47])([OH:22])=[O:8]

Participants

5

Reactant 4

HCID 5950L-AlanineHCID 178500438HCID 178500438, compoundHCID 178500439HCID 178500439, compoundHCID 178512944HCID 178512944, compound

Product 1

HCID 178454579HCID 178454579, compound

Procedure

By substituting nitro-L-arginine benzyl ester for the L-alanine in the procedure of Example 1, and then treating the product by the procedures of Examples 2 and 3, Nα -(3-methoxycarbonyl-2-methylpropanoyl)-nitro-L-arginine benzyl ester, Nα -(3-methoxycarbonyl-2-methylpropanoyl)-L-arginine and Nα -(3-carboxy-2-methylpropanoyl-L-arginine are obtained.

Sources & evidence

ORD record
ord-61f69e983849443a9c293c6d03232f6e
Source dataset
uspto-grants-1980_10
Patent number
US04228184

Reaction notes

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