HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → 2-(2-Hydroxyethoxymethyl)pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Pyrazine, 2-(chloromethyl)- | HCID 170169 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Product | 2-(2-Hydroxyethoxymethyl)pyrazine | HCID 20567544 | — |
Reaction Steps
2-Chloromethylpyrazine is reacted with the sodium salt of ethylene glycol to give 2-(2-hydroxyethoxymethyl)pyrazine which is treated with thionyl chloride to give 2(2-chloroethoxymethyl)pyrazine. Using this intermediate in place of 4-(3-chloropropoxy)methylimidazole in the procedure of Example 22 gives the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04228291 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-d0b93b3c31e34b7198e734dc579c9efd |
| Source note | uspto-grants-1980_10 |