Ethylenediamine → HCID 178484973, compound

HRID 903727Notes

Reaction equation

HRID 903727 reaction equation
ClC[C:3]1[N:8]=[CH:7]C=[CH:5][N:4]=1.C(N)C[NH2:11].[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[CH2:19][NH:20][CH2:21][CH2:22][NH2:23].CN=C=S>>[C:5]([NH:4][C:3]([NH:8][CH3:7])=[N:23][CH2:22][CH2:21][NH:20][CH2:19][C:14]1[N:15]=[CH:16][CH:17]=[CH:18][N:13]=1)#[N:11]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 11167Methyl isothiocyanateHCID 128773712-(Chloromethyl)pyrimidineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 178484973HCID 178484973, compound

Procedure

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]-thiourea. This thiorea is reacted with lead cyanamide by the procedure of Example 3(b) to give the title compound.

Workup

  1. customgives
  2. concentrationafter concentrating
  3. customThis thiorea is reacted with lead cyanamide by the procedure of Example 3(b)

Sources & evidence

ORD record
ord-aa4d354fbfc944d2a7ff608b1825904c
Source dataset
uspto-grants-1980_10
Patent number
US04228291

Reaction notes

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