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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 903732Generated: October 26, 2026

Ethyl isothiocyanate → N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea

https://huagongshe.com/reaction/903732

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl isothiocyanateHCID 10966—
ReactantN-(pyrazinylmethyl)ethylenediamineHCID 13910894—
ProductN-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thioureaHCID 20567640—

Reaction Steps

Reacting N-(2-pyrazinylmethyl)ethylenediamine with ethyl isothiocyanate by the procedure of Example 3 and chromatographing gives N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3 gives N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylamino)ethyl]-guanidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04228291
Source datasetuspto-grants-1980_10
ORD IDord-99bf4d9cd0884ff6be37530fdf497190
Source noteuspto-grants-1980_10