HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylenediamine → N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 5-Benzyl-4-chloromethyloxazole | HCID 20557836 | — |
| Reactant | HCID 20567646 | HCID 20567646 | — |
| Product | N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]thiourea | HCID 20557842 | — |
Reaction Steps
Reacting ethylenediamine with 5-benzyl-4-chloromethyloxazole by the procedure of Example 34, then reacting the resulting N-(5-benzyl-4-oxazolylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) and chromatographing gives N-methyl-N'-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3(b) gives N-[2-((5-benzyl-4-oxazolyl)methylamino)ethyl]-N'-cyano-N"-methylguanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04228291 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-d3ce75994e3b4bb886eeb7eab2bc4805 |
| Source note | uspto-grants-1980_10 |