Potassium Bicarbonate → HCID 23335159, compound

Participants

Reaction Steps

3-(4-Fluorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid (3.40 mmol) is stirred together with 0.34 g (3.40 mmol) potassium bicarbonate in 10 ml THF/DMF (1:1) for 15 minutes. Then 3.40 mmol of 3-benzylpyrrolylmethyl methanesulfonate in 5 ml THF/DMF (1:1) is added and the mixture stirred for approximately 48 hours. The reaction is diluted with ether, washed with water (3X) and sat. NaCl, dried and solvent is removed. The crude product is purified by preparative TLC developing with 10% ethyl acetate/hexane to yield 3-benzylpyrrolylmethyl 3-(4-fluorophenoxy)-2,2-dimethylcyclopropanecarboxylate.

Provenance & Evidence