HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 903815Generated: October 31, 2026
1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene
https://huagongshe.com/reaction/903815
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloro-4-nitrobenzene | HCID 7443 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Chloro-1-fluoro-4-nitrobenzene | HCID 67688 | 81% |
Reaction Steps
A suspension of 1,500 parts of 3,4-dichloronitrobenzene, 900 parts of potassium fluoride and 10 parts of cesium fluoride in 800 parts of dimethylformamide is refluxed for 16 hours (165° C.). The mixture is worked up as described in Example 1(a). 1,110 parts (81% of theory) of 3-chloro-4-fluoronitrobenzene of melting point 41°-42° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04229365 |
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| Source dataset | uspto-grants-1980_10 |
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| ORD ID | ord-e321998af2bf4506a2c5be085f401928 |
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| Source note | uspto-grants-1980_10 |
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