HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → 1,2-Difluoro-4-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | 2-Chloro-1-fluoro-4-nitrobenzene | HCID 67688 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Product | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | 10.3% |
Reaction Steps
1,500 parts of 3-chloro-4-fluoronitrobenzene, 25 parts of cesium fluoride and 1,000 parts of potassium fluoride are heated in 1,500 parts of tetramethylenesulfone for 16 hours at 230° C. The mixture is worked up as described in Example 1(a). 139 parts (10.3% of theory) of 3,4-difluoronitrobenzene of boiling point 54° C./1 mm Hg are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04229365 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-b13723a9ad2d471ab1365bff10d235c1 |
| Source note | uspto-grants-1980_10 |