反应详情

A solution of (-)-α-amino-3-(chloromethyl)-4-hydroxybenzeneacetic acid (0.5 g, 1.98 mmole) and potassium thiocyanate (0.4 g, 4.12 mmole) in 10 ml of methanol is stirred at room temperature for 16 hours. The reaction mixture is filtered to remove the potassium chloride, the filtrate is evaporated and to the residue is added saturated aqueous sodium bicarbonate until the pH is 7. The title compound precipitates as a white powder which is filtered and dried. (1.83 g, 78% yield), NMR (TFA-D+D2O) ppm (δ) 4.1 (s,2), 5.08 (s,1), 6.9-7.3 (m,3).

1. filtrationThe reaction mixture is filtered
2. customto remove the potassium chloride
3. customthe filtrate is evaporated and to the residue
4. additionis added saturated aqueous sodium bicarbonate until the pH is 7
5. customThe title compound precipitates as a white powder which
6. filtrationis filtered
7. customdried