HCID 20296133, compound → HCID 23329777, compound

HRID 903832Notes

Reaction equation

HRID 903832 reaction equation
[NH2:1][C:2]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH2:16]Cl)[CH:10]=1)[C:6]([OH:8])=[O:7])=[O:3].[H][H]>O.[Pd]>[NH2:1][C:2]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH3:16])[CH:10]=1)[C:6]([OH:8])=[O:7])=[O:3]

Participants

5

Reactant 2

HCID 20296133HCID 20296133, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23329777HCID 23329777, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of α-(aminocarbonyl)amino-3-chloromethyl-4-hydroxybenzeneacetic acid (0.1 mole) and 10% Pd on charcoal (1 g) catalyst in 50 ml of water is subjected to hydrogen gas at a pressure of about 60 pounds/in2 at room temperature for a period of about 16 hours. Removal of the catalyst followed by evaporation of the water gives the title compound.

Workup

  1. customin2 at room temperature
  2. customof about 16 hours
  3. customRemoval of the catalyst
  4. customfollowed by evaporation of the water

Sources & evidence

ORD record
ord-8037b0601c5143339eceaef8eb30bc74
Source dataset
uspto-grants-1980_10
Patent number
US04229363

Reaction notes

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