HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxobutanoic Acid → Thiazolidinecarboxylic acid, 2-ethyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxobutanoic Acid | HCID 58 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Thiazolidinecarboxylic acid, 2-ethyl- | HCID 198462 | 65.8% |
Reaction Steps
11.4 g of cysteamine hydrochloride and 10.1 g of triethylamine were dissolved in 100 ml of ethanol, to which was added 10.2 g of 2-keto-butyric acid. The mixture was refluxed for 30 minutes, cooled and filtered thereby giving 10.6 g (yield 65.7%) of 2-ethyl-thiazolidine-2-carboxylic acid with a melting point of 235°-238° C. (decomposed).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04229461 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-6417e3b5d0cb4c31933f5935b2dc8ca2 |
| Source note | uspto-grants-1980_10 |