2-Ethyl-3-(3,5-dichlorophenylcarbamoyl) thiazolidine-2-carboxylic acid methyl ester → 7a-Ethyl-6-(3,5-dichlorophenyl)perhydroimidazo[5,1-b]thiazole-5,7-dion
Reaktionsgleichung
C[O:2][C:3]([C:5]1([CH2:21][CH3:22])[N:9]([C:10](=[O:20])[NH:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[CH2:8][CH2:7][S:6]1)=O>C[O-].[Na+].CO>[CH2:21]([C:5]12[C:3](=[O:2])[N:11]([C:12]3[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=3)[C:10](=[O:20])[N:9]1[CH2:8][CH2:7][S:6]2)[CH3:22]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
0.70 g of 2-ethyl-3-(3,5-dichlorophenylcarbamoyl)thiazolidine-2-carboxylic acid methyl ester was added to 20 ml of 0.1 N sodium methylate-methanol solution, heated at 50° C. for 20 minutes. The reaction mixture was cooled and filtered. The resulting filtrate was 0.16 g (yield 25%) of 7a-ethyl-6-(3,5-dichlorophenyl)perhydroimidazo[5,1-b]thiazole-5,7-dion (compound No. 7). The results of elementary analysis and a melting point were given in table 1.
Aufarbeitung
- temperatureThe reaction mixture was cooled
- filtrationfiltered
Quellen und Nachweise
- ORD-Eintrag
- ord-0a471cf24cf248e793974a089fba4f27
- Quelldatensatz
- uspto-grants-1980_10
- Patentnummer
- US04229461
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