1-Methylpiperazine → HCID 13464029, compound

Participants

Reaction Steps

A mixture of 5-bromo-11-methylenebenzo[5,6]cyclohepta[1,2-c]pyridine (11.0 g.), 1-methylpiperazine (7.8 ml.), potassium tert.-butoxide (8.4 g.) and tert.-butanol (150 ml.) is heated under reflux for 4 hours. The tert.-butanol is removed in vacuo and the residue is taken up in methylene chloride (600 ml.). The resulting mixture is washed with 10% NaCl solution, saturated NaCl solution, and dried (anhydrous Na2SO4). Filtration and removal of the solvent gives 10.76 g. of dark amber oil.

Provenance & Evidence