Benzene, 1-isocyanato-2-methoxy- → HCID 178489601, compound

HRID 903905Notes

Reaction equation

HRID 903905 reaction equation
Cl.[NH:2]1[CH2:6][CH2:5][NH:4][C:3]1=[N:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18])=[O:9].N=C1NCCN1.COC1C=CC=CC=1N=C=O>>[NH:2]1[CH2:6][CH2:5][NH:4][C:3]1=[N:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18])=[O:9]

Participants

4

Reactant 3

HCID 69695Benzene, 1-isocyanato-2-methoxy-HCID 178489602HCID 178489602, compoundHCID 178508455HCID 178508455, compound

Product 1

HCID 178489601HCID 178489601, compound

Procedure

N-(2-Imidazolidinylidene)-N'-(2-methoxyphenyl)urea.hydrochloride, m.p. 197°-199.5° C., by reacting 2-iminoimidazolidine (prepared from 2-iminoimidazolidine hydroiodide and lithium hydride) and 2-methoxyphenyl isocyanate at about 5° to 10° C. to obtain a N-(2-imidazolidinylidene)-N'-(2-methoxyphenyl)urea product, followed by reacting the urea base with methanolic hydrogen chloride and recrystallizing first from methanol/2-propanol, then twice from methanol ether.

Workup

  1. customat about 5° to 10° C.

Sources & evidence

ORD record
ord-cf41b96d350a4abaafbe404679839c64
Source dataset
uspto-grants-1980_10
Patent number
US04229462

Reaction notes

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