反应详情

0.4 g (1.03 mmoles) of 3-methyl-6-tetradecyloxy-benzofuran-2-carboxylic acid and 0.3 g (2.00 mmoles) of 1-methyl-3-p-tolyltriazine are stirred in ether and refluxed for 15 minutes. The mixture is then allowed to stand at room temperature for 1 hour. It is then refluxed for 15 minutes. The reaction mixture is worked-up by extraction with diethyl ether and HCl. The ether is distilled off and is replaced by dioxane. The resultant mixture is heated on a steam bath for 1 hour. It is then extracted with diethyl ether/HCl, H2O and NaHCO3 (aq.). The extract is evaporated and the ether replaced with methanol. The methyl ester of 3-methyl-6-tetradecyloxy-benzofuran-2-carboxylic acid is allowed to crystallize from the mixture.

1. temperaturerefluxed for 15 minutes
2. temperatureIt is then refluxed for 15 minutes
3. extractionThe reaction mixture is worked-up by extraction with diethyl ether and HCl
4. distillationThe ether is distilled off
5. temperatureThe resultant mixture is heated on a steam bath for 1 hour
6. extractionIt is then extracted with diethyl ether/HCl, H2O and NaHCO3 (aq.)
7. customThe extract is evaporated
8. customto crystallize from the mixture