Butoctamide → HCID 23335626, compound

Participants

Reaction Conditions

Reaction Steps

In a flask, 10 g of N-(2-ethylhexyl)-β-hydroxybutyramide semisuccinate was admitted and heated at 170° C. for 4 hours. The reaction mixture was dissolved in n-hexane and the insolubles were removed by filtration. The filtrate was washed first with diluted hydrochloric acid and then with 10% sodium hydroxide solution, and subsequently dried with sodium sulfate. The residue was recrystallized from n-hexane, obtaining 5.01 g of N-(2-ethylhexyl)-crotonamide (yield: 80.1%). This compound showed substantially the same results as those in Example 1.

Provenance & Evidence